Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Lung Cancer Group, University of Cologne, Cologne, Germany. Onkologische Praxis Moers, Moers, Germany. Faculty of Medicine and University Hospital Cologne, Center for Pharmacology, Department I of Pharmacology, University of Cologne, Cologne, Germany. Faculty of Medicine and University Hospital Cologne, Institute for Diagnostics und Intervention Radiology, University of Cologne, Cologne, Germany. Faculty of Medicine and University Hospital Cologne, Department for Nuclear Medicine, University of Cologne, Cologne, Germany. Faculty of Medicine and University Hospital Cologne, Institute for Pathology, University of Cologne, Cologne, Germany. Faculty of Medicine, Institute for Medical Statistics and Bioinformatics, University of Cologne, Cologne, Germany. Max Planck Institute for Metabolism Research, Cologne, Germany. Praxis for Medical Oncology and Haematology (PIOH), Frechen, Germany. Heamatology and Oncology, Augusta Hospital, Bochum, Germany. Bethanien Hospital, Solingen, Germany. Medical Oncology and Haematology, St. Marien Hospital, Düren, Germany. Institute for Biomedical and Pharmaceutical Research (IBMP), Nürnberg, Germany. Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, China. Hunan Key Laboratory for Bioanalysis of Complex Matrix Samples, Changsha, China.